Enclomiphene citrate

CAS No. 7599-79-3

Enclomiphene citrate( E)-Clomifene | cis-Clomifene | RMI-16289 | ICI-46476 )

Catalog No. M15886 CAS No. 7599-79-3

Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476)?is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 43 In Stock
10MG 67 In Stock
25MG 122 In Stock
50MG 202 In Stock
100MG 299 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Enclomiphene citrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476)?is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism.
  • Description
    Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476)?is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism; inhibits the ER in the pituitary gland, reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, increases gonadotropin secretion and hence gonadal production of testosterone.Sexual Dysfunction Phase 3 Clinical(In Vitro):Enclomiphene citrate (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion.Enclomiphene citrate (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes.Enclomiphene citrate (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells.(In Vivo):Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats.Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol.
  • In Vitro
    Enclomiphene citrate (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion.Enclomiphene citrate (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes.Enclomiphene citrate (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells.
  • In Vivo
    Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats.Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol. Animal Model:21 days-old Charles River male rats Dosage:0.25 and 0.5 mg/animal, daily for 24 days. Administration: Subcutaneous injection Result:Decreased LH and testosterone levels in the serum.Animal Model:OVX (ovariectomy) rat model Dosage:0.03, 1, and 3 mg/kg, daily for 90 days.Administration:Oral adminstration Result:Reducted body weight to sham levels, and reduced serum cholesterol.Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
  • Synonyms
    E)-Clomifene | cis-Clomifene | RMI-16289 | ICI-46476
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen Receptor/ERR
  • Research Area
    Endocrinology
  • Indication
    Sexual Dysfunction

Chemical Information

  • CAS Number
    7599-79-3
  • Formula Weight
    598.089
  • Molecular Formula
    C32H36ClNO8
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
  • Chemical Name
    (E)-2-(4-(2-chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hill S, et al. IDrugs. 2009 Feb;12(2):109-19. 2. Marth C, et al. Biochem Pharmacol. 1984 Dec 15;33(24):3951-6. 3. Wilcox JN, et al. Brain Res. 1983 May 5;266(2):243-51. 4. Huang ES, et al. Endocrinology. 1983 Feb;112(2):442-8.
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