
Enclomiphene citrate
CAS No. 7599-79-3
Enclomiphene citrate( E)-Clomifene | cis-Clomifene | RMI-16289 | ICI-46476 )
Catalog No. M15886 CAS No. 7599-79-3
Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476)?is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 43 | In Stock |
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10MG | 67 | In Stock |
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25MG | 122 | In Stock |
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50MG | 202 | In Stock |
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100MG | 299 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameEnclomiphene citrate
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NoteResearch use only, not for human use.
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Brief DescriptionEnclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476)?is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism.
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DescriptionEnclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476)?is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism; inhibits the ER in the pituitary gland, reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, increases gonadotropin secretion and hence gonadal production of testosterone.Sexual Dysfunction Phase 3 Clinical(In Vitro):Enclomiphene citrate (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion.Enclomiphene citrate (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes.Enclomiphene citrate (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells.(In Vivo):Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats.Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol.
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In VitroEnclomiphene citrate (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion.Enclomiphene citrate (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes.Enclomiphene citrate (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells.
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In VivoEnclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats.Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol. Animal Model:21 days-old Charles River male rats Dosage:0.25 and 0.5 mg/animal, daily for 24 days. Administration: Subcutaneous injection Result:Decreased LH and testosterone levels in the serum.Animal Model:OVX (ovariectomy) rat model Dosage:0.03, 1, and 3 mg/kg, daily for 90 days.Administration:Oral adminstration Result:Reducted body weight to sham levels, and reduced serum cholesterol.Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
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SynonymsE)-Clomifene | cis-Clomifene | RMI-16289 | ICI-46476
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen Receptor/ERR
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Research AreaEndocrinology
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IndicationSexual Dysfunction
Chemical Information
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CAS Number7599-79-3
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Formula Weight598.089
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Molecular FormulaC32H36ClNO8
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
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Chemical Name(E)-2-(4-(2-chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hill S, et al. IDrugs. 2009 Feb;12(2):109-19.
2. Marth C, et al. Biochem Pharmacol. 1984 Dec 15;33(24):3951-6.
3. Wilcox JN, et al. Brain Res. 1983 May 5;266(2):243-51.
4. Huang ES, et al. Endocrinology. 1983 Feb;112(2):442-8.
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